TGF (Tissue Growth Factor) beta-1 Cream
EDS Skin Care Forums Forum Index » Skin Care and Makeup Forum

free skin care · Sat Feb 12, 2011 10:53 pm

loribar wrote:

Okay...you gals are waaay better at comparing ingredients/products....I'm wondering how this cream stacks up to Jan Marini's transformation cream, which is also a tgf beta 1 cream. I've used it and felt like it was beneficial in alot of ways to my skin.

I'm tired and my brain isn't working well, but hasn't there been some negative discussion about tgf beta 1 awhile back?? I honestly don't remember any of the specifics, but I do remember thinking uh oh, I use a product with that in it.

I think there are questions raised with ALL
growth factors including plant sourced and human sourced. If they can stimulate cell growth, how do they affect cancer cells? (something we all have yet may or may not become cancerous).

http://en.m.wikipedia.org/wiki/Transforming_growth_factor_beta?wasRedirected=true

Transforming growth factor beta (TGF-β) is a protein that controls proliferation, cellular differentiation, and other functions in most cells. It plays a role in immunity, cancer, heart disease, diabetes, and Marfan syndrome. TGF-beta acts as an antiproliferative factor in normal epithelial cells and at early stages of oncogenesis.[1]

Some cells secrete TGF-β, and also have receptors for TGF-β. This is known as autocrine signalling. Cancerous cells increase their production of TGF-β, which also acts on surrounding cells.

TGF-β is a secreted protein that exists in three isoforms called TGF-β1, TGF-β2 and TGF-β3. It was also the original name for TGF-β1, which was the founding member of this family. The TGF-β family is part of a superfamily of proteins known as the transforming growth factor beta superfamily, which includes inhibins, activin, anti-müllerian hormone, bone morphogenetic protein, decapentaplegic and Vg-1.

free skin care · Sun Feb 13, 2011 2:42 am

loribar wrote:

Okay...you gals are waaay better at comparing ingredients/products....I'm wondering how this cream stacks up to Jan Marini's transformation cream, which is also a tgf beta 1 cream. I've used it and felt like it was beneficial in alot of ways to my skin.

Here's the ingredients for JM Transformation Cream:

Water (Aqua), Hexyl Laurate, Caprylic/ Capric Triglyceride, Butylene Glycol, Glycerin, Yeast Extract, Polysorbate 60, Stearyl Alcohol, Palmitic Acid, Sorbitan Stearate, Elastin, Sodium Hyaluronate, Myristoyl Pentapeptide-8, Myristoyl Pentapeptide-11, Recombinant VEGF 165, Recombinant TGF-Beta 1, Thymosin Beta 4, Retinyl Palmitate, Tocopherol, Ascorbyl Palmitate, Ascorbic Acid, Citric Acid, Aloe Barbadensis Leaf Juice, Tocopheryl Acetate, Tocopheryl Linoleate, Squalane, Dimethicone, Sodium PCA, C12-20 Acid PEG-8 Ester, Cetyl Alcohol, PEG-8, Nylon 12, Phenoxyethanol, Methylparaben, Butylparaben, Ethylparaben, Propylparaben, Imidazolidinyl Urea, Diazolidinyl Urea, Fragrance (Parfum)

I don't know that I can see much correlation with the Reviva Labs' ingredients - anyone else have an opinion?

free skin care · Sun Feb 13, 2011 8:08 am

This article may help explain the TGF better.

http://findarticles.com/p/articles/mi_hb4393/is_7_35/ai_n29106334/

The Reviva uses SYN-coll from what I can see of the ingredients and not TGF.

SYN®-COLL is a patented innovative approach that is based on Pentapharm’s many years of experience in synthesizing peptides for the pharmaceutical industry. SYN®-COLL is a small peptide with a unique sequence to mimic the human body’s own mechanism to produce collagen via TGF-β.

free skin care · Sun Feb 13, 2011 8:31 am

Suk Han wrote:

InkyProse:

Thank you for your response. I need to firm my cheek, under my chin, my neck, and...... Sad

I have neck line. I wish this cream may help a little too. I have been using Vit. C (Kassy's C formula) and Retin A. It helps a lot.

Thank you again!

Hi Suk,

I haven't been using it on my neck, tho I should. It sounds like you might need to work on your muscles in those areas perhaps?

free skin care · Sun Feb 13, 2011 8:47 am

DarkMoon wrote:

... It plays a role in immunity, cancer, heart disease, diabetes, and Marfan syndrome. TGF-beta acts as an antiproliferative factor in normal epithelial cells and at early stages of oncogenesis.[1]

DarkMoon wrote:

... Cancerous cells increase their production of TGF-β, which also acts on surrounding cells.

Pardon my ignorance, please. I just would like to understand what exactly it means...

What role does it play in immunity, heart disease..etc? And what does it do in relation to cancerous cells?
Does it promote or suppress them?

free skin care · Sun Feb 13, 2011 2:30 pm

ella-stella wrote:

DarkMoon wrote:

... It plays a role in immunity, cancer, heart disease, diabetes, and Marfan syndrome. TGF-beta acts as an antiproliferative factor in normal epithelial cells and at early stages of oncogenesis.[1]

DarkMoon wrote:

... Cancerous cells increase their production of TGF-β, which also acts on surrounding cells.

Pardon my ignorance, please. I just would like to understand what exactly it means...

What role does it play in immunity, heart
disease..etc? And what does it do in relation to cancerous cells?
Does it promote or suppress them?

What I wrote is questions have been raised some
right on this forum, if a substance causes proliferation of healthy cells (as we would like) will they also cause proliferation of cancer cells (assuming they reach that deep, skin cancerous or precancerous cells aside). I don't think this has ever been definitively answered?

Just a few abstracts to read, if interested you
search for more about their role in each disease mentioned?

http://humrep.oxfordjournals.org/content/16/6/1291.short

http://cgp.iiarjournals.org/content/7/4/217.abstract

http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=30469

http://clincancerres.aacrjournals.org/content/16/5/1416

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