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Thu Mar 23, 2006 12:22 am  |
OK I just read this, what do you think? How much is too much, and is using a glycolic or other types of exfoliators causing accelerated aging?
"The dangers of excessive skin exfoliation:
Less wrinkles today could mean more wrinkles tomorrow
Main benefits of alpha hydroxy acids come from their ability to exfoliate skin. Removal of the outermost layer of the skin stimulates the cells in lower layers to grow and divide, causing the skin to thicken and thus diminishing visible signs of aging. The more you exfoliate the more cell divisions will occur in the lower skin layers. There is one problem though. Normal human cells cannot divide indefinitely. Fibroblasts (a key type of cells in the skin) would divide about fifty times and then enter a so-called stage of senescence. This limit of about fifty cell divisions is called the Hayflick limit (after its discoverer, Dr. Leonard Hayflick). This is a state in which the cell is sluggish, inefficient, unresponsive to various signals from the body and unable to divide. Skin with many senescent cells is usually fragile blotchy and easily wrinkled.
Exfoliation remains a valuable cosmetic tool but if you overuse it, your skin may "hit the Hayflick limit" earlier than it should. In recent years, researchers have discovered the molecular mechanism of the Hayflick limit. (It has to do with the areas at the tips of chromosomes called telomeres). Medical technologies to eliminate the Hayflick limit may appear in a reasonably near future. These technologies are likely to work only for those cells whose Hayflick limit has not yet been reached.
Today's good news is that Hayflick limit does not appear to be carved in stone. Research indicates that very simple measures available today may help extend it by as much as 50 percent. (Further details are included in the Skin Rejuvenation Infopack ). "
http://users.erols.com/gtodorov/skincare/aha_bha.htm |
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Thu Mar 23, 2006 9:51 am |
JMHO, I think there may be something to it. I mean there are theories that our hearts are pre-programmed to beat a certain number of times based on our genes (can be altered by lifestyle of course), why not skin? I think there MAY BE a limited to a number of turnover until cells just give up.
I just don't know what to believe any more 
"Everything is good in moderation" probably works for peels and microderms, too. |
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Thu Mar 23, 2006 10:27 pm |
Hi pumaka - Here's a snippet I found that is essentialy like other things I've read that refute the Hayflick Theory:
Hayflick limit
In 1961 Leonard Hayflick and Paul Moorhead demonstrated that human cells in culture can only divide a limited amount of times. This phenomenon, is called replicative senescence. Hayflick's theory illustrates two pitfalls. He presumed that cells in culture had all that is needed for survival, which may not be so. An undetectable deficiency of a growth factor may let cells divide only a limited amount of times. After all most cancer cells can divide in vitro for ever.
The second pitfall is known here as context fallacy, A phenomenon discovered in a narrow context (petri dish) is applied as such to the wider context of the organism. Certain cell lines such as hemopoietic cells, bone marrow, epithelial cells in the skin and gastrointestinal mucosa, endure many more population doublings in vivo than they do in vitro. Hayflick limit is a laboratory artifact which does not apply to the organism. |
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Fri Aug 09, 2013 4:10 am |
Hi all,
I have skin that is very lined, dehydrated, wrinkly and creepy looking, with large pores, scars and purple/brown marks from acne also. For the last six months or so, it seems to not 'work' properly. Products don't seem to sink in, even oils, skin appears very damaged and dented with thousands of fine lines, unable to respond etc.
I had been told that due to extreme over exfoliation I had ruined my skin barrier and had severe dehydration. Another cosmetic skin specialist told me about the Hayflick theory and said that it seems that my case gives it some credence, as my skin literally seemed to age 10-15 years in a couple months.
For the record I am Caucasian male, early twenties. I sincerely hope I haven't reached my cell limit and caused extreme aging. I am very depressed over this. 
Anyway, just don't over exfoliate! Check the ph balance of your products, and less is definitely more.
*dream* |
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