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Thu May 17, 2007 7:54 am  |
Taz is a different retinoid than Retin A. It is synthetic. It acts on different receptors than Retin A.
This is from tetrakis' notepad on makeupalley.com:
"retin A is a natural retinoid (aka retinoic acid, tretinoin) derived from vitamin a . IIRC, it activates all of the RAR type retinoid receptors to elicit it's effects on the skin (collagen production, collagen protection, possibly DNA repair, clearing the pores , normalizing keratin production to keep the pores clear, speeding up cell turn over, etc).
Tazorac is a synthetic retinoid (meaning it is not derived from vitamin a), but it also activates RAR receptors (though no evidence that it might activate RXR's too, which tretinoin *might*). Basically, scientists used what they figured out about how retin-a works to design this drug so that it is targeted to specific actions in the skin.
Tazarotene activates 3 (RAR), but binds even tighter than tretinoin = very strong retinoid (studies show it may be better than tretinoin for treating photoaging)." |
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