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Sun Apr 24, 2011 9:30 am  |
....does quite a bit more than that^^
Niacinamide has been extensively studied and proven to increase the rate of collagen synthesis, lighten and even skin tone, reduce and eliminate acne as well as improve the skin's own production of Hyaluronic acid. Niacinamide also reduces sebum production thereby reducing the appearance of pore size. [ effective at 2% in clinical trails ]
Niacimamide aids in the increase of ceramide production in the skin and improves skin barrier function. TEWL [ trans epidermal water loss ] is reduced. Vitamin B3 has also been shown to increase the production of NADPH in older skin to that of levels as once produced in youth.
DNA is the rare biomolecule that is not discarded when it is damaged, but rather is repaired. Human cells have developed two fundamental repair strategies to restore DNA to its native sequence and conformation.
More than 20 different proteins participate in this multistep process, and many of these proteins also participate in RNA transcription and/or DNA synthesis. The process of DNA repaid relies on the presence of Nicotinamide adenine dinucleotide {NAD} which is rapidly depleted during the repair process. Niacinamide is member of the the vitamin B family and is crucial that it is in reserve for dermal cells to replenish NAD.
Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. B J Dermatol 2000; 143:525¿531.
Gensler HL. Prevention of photoimmunesuppression and photocarcinogenesis by topical niacinamide. Nutr Cancer 1997; 29:157-162.
Yu J-M, Liu Y, Xie N, Sun W, Wang J-J, Li H-Q. Effects of nicotinamide on levels of dermis hydroxyproline in photoaging skin. Huanjing Yu Jiankang Zazhi 2002; 19:102-104.
Shalita AR, Smith JG, Parish LC, Sofman MS, Chalker DK. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int J Dermatol 1995; 34:434-437.
Girffiths CEM. Nicotinamide 4% gel for the treatment of inflammatory acne vulgaris. J Dermatol Treat 1995; 6:S8¿S10. |
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