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Sat Aug 18, 2007 9:12 pm  |
Is anyone concerned about the study linking overuse of HA to breast cancer? I am not certain of the amount that is too much... I have read this thing several times and it just goes above my head...maybe someone can decipher this because my brain is not wrapping around it at all.
Department of Pathology, McGill University, Montreal, Quebec, Canada.
Hyaluronan (HA) is a high molecular weight glycosaminoglycan present mostly in the extracellular matrix (ECM). HA binds to specific receptors such as CD44. Its production is increased at the tumour-stroma interface, including those in breast cancer tumours. It has been suggested that it facilitates invasion of tumour cells into the ECM by a hydrodynamic effect, or by altering tumour cell behaviour. Using in vitro tests we studied the effect of immobilized (iHA) and soluble (sHA) HA on the invasive properties of four human breast cancer cell lines with different levels of CD44 expression. Our results show that iHA acts as an adhesive, haptotactic, and motility stimulating factor for the CD44 positive Hs578T cells and induces the expression of membrane CD44. sHA also changes the motility properties of the Hs578T and MDA-231 cells and increases their CD44 expression. sHA or iHA have no measurable effect on the adhesion, motility or CD44 expression of the ZR-75-1 and MCF-7 breast cancer cells. Our results establish that in high CD44 expressing breast cancer cells HA modulates tumour cell adhesion and motility and also increases the expression of its own receptor, CD44.
PMID: 11488992 [PubMed - indexed for MEDLINE]
What the heck? A friend sent this to me and we are both confused. I take a supplement for joint/bone health that contains HA so I have not added HA supplements. I tried to search to see if this was discussed but did not find it. If so, sorry I missed it.
Edited to include link (also check out the reports on the right side of the page involving HA)
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=11488992&dopt=AbstractPlus
This may mean nothing... I just cannot figure it out.
Deb |
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| Sat Nov 23, 2024 1:13 am |
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