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Sun Apr 22, 2012 6:08 am  |
What do you all think about liposomes? Beneficial or detrimental to our skin? I've read they are good because they help beneficial ingredients go deeper into our skin. But then during my search of the forum, someone posted this from Dr. Pickart (I'm not sure who that is but it seems some here do?)
"It seems very silly to use liposomes to load enzymes into your skin cells to try to repair photodamage. The liposome push junk into all the skin cells such as keratinocytes, nerve cells, immune cells in the skin, fat cells, etc - not just the photodamaged cells. The enzymes used are not human but from marine organisms. In time, the human body's immune system will recognize these alien proteins and activate an immune response which will produce an allergic response."
So which is true about liposomes? I have rosacea and a product I'd like to use (that also calms my rosacea) has liposomes in it, but after reading that I fear I'm doing more damage than good by using it.  |
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Sun Apr 22, 2012 9:19 am |
| egyptiangoddess wrote: |
What do you all think about liposomes? Beneficial or detrimental to our skin? I've read they are good because they help beneficial ingredients go deeper into our skin. But then during my search of the forum, someone posted this from Dr. Pickart (I'm not sure who that is but it seems some here do?)
"It seems very silly to use liposomes to load enzymes into your skin cells to try to repair photodamage. The liposome push junk into all the skin cells such as keratinocytes, nerve cells, immune cells in the skin, fat cells, etc - not just the photodamaged cells. The enzymes used are not human but from marine organisms. In time, the human body's immune system will recognize these alien proteins and activate an immune response which will produce an allergic response."
So which is true about liposomes? I have rosacea and a product I'd like to use (that also calms my rosacea) has liposomes in it, but after reading that I fear I'm doing more damage than good by using it. |
Liposomes are merely delivery vehicles that allow actives to better penetrate the outer layer of skin (stratum corneum). Once they get past that barrier, they are mainly broken down and the active released.
I can't speak for Dr Pickard but form the quote you gave I imagine he was concerned about enzymes in particular, and crossing into cells deeper in the epidermis. Enzymes tend to be very large molecules, and are made inside cells, where they are used. Some are exported from cells (e.g. proteases), but few are imported into cells (if the cell needs it makes it. Most enzymatic pathways are not so much enzyme dependent, but substrate dependent in terms of activity levels, which means having more enzyme isn’t going to do much anyway. Dr. P may also be concerned about delivering enzymes to the wrong place at the wrong time, which can create more problems rather than solving any.
Liposomes have become a bit of a marketing buzz word. Some claim to have them but really don’t, and if you don’t do them right they are very unstable in products anyway (short half-life). They tend to fall apart easily.
To answer your question, liposomes are a good thing in general to get actives into your skin. But they can be bad things if what you are delivering is the wrong thing, to the wrong place, or at the wrong time.
PS My colleague Dr George has rosacea, and has lots of expertise. Look at his rosacea posts on BFT - you might find some useful information there. |
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Fri May 04, 2012 4:32 am |
Thanks DrJ. That helped a lot. 
I wonder if you'd mind giving me some advice DrJ? The lotion I was speaking about is called "Earth Science Almond Aloe moisturizer Fragrance-free." I'm on the hunt for a new facial moisturizer as my current one has been discontinued  I am not having very much success. However, I quite like this one for a basic moisturizer. (I used to use this every day about 4 or 5 years ago and loved it.) It REALLY helps my rosacea and any redness/inflammation I have. I'm having an awful time with my skin right now, including melasma. I am uncertain if the ingredients of this lotion are okay or not for rosacea/melasma. It definitely helps rosacea but I worry about if it would help or hurt melasma. Perhaps you might know? The ingredients of this lotion from the bottle are:
Water, Glycerin, Glyceryl Stearate, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Ceteareth-5, Dimethicone, Simmondsia Chinensis (Jojoba) Seed Oil, Aloe Barbadensis Leaf Juice, Panax Ginseng Root Extract, Squalane, Vegetable oil, Glycine Soya (Soybean) Sterols, Soya Liposomes, Tocopherol, Chamomilla Recutita (Matricaria) Flower Oil, Geranium Maculaturn Oil, Allantoin, Ascorbic Acid, Sodium Hyaluronate, Xanthan Gum, Lactic Acid, Beta Carotene, Glycyrrhiza Glabra (Licorice) Root Extract, Retinyl Palmitate, Glyceryl Dilaurate, Citrus Grandis (Grapefruit) Seed Extract, Sodium Cocoyl Isethionate, Potassium Sorbate, Sodium Hydroxymethylglycinate, Phenoxyethanol.
I hope I typed that out right lol. I know for example, that chamomile is good for rosacea and inflammation. As well as licorice. And licorice is good for melasma/discoloration. However, it has Geranium oil, which I've read is a photosensitizer. And it also has liposomes!
I am trying to do the best things I can for my skin right now and I am so confused.  I also got some broken capillaries from using a retinol cream for some reason. Sigh |
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Fri May 04, 2012 7:12 am |
| egyptiangoddess wrote: |
Thanks DrJ. That helped a lot.
I wonder if you'd mind giving me some advice DrJ? The lotion I was speaking about is called "Earth Science Almond Aloe moisturizer Fragrance-free." I'm on the hunt for a new facial moisturizer as my current one has been discontinued I am not having very much success. However, I quite like this one for a basic moisturizer. (I used to use this every day about 4 or 5 years ago and loved it.) It REALLY helps my rosacea and any redness/inflammation I have. I'm having an awful time with my skin right now, including melasma. I am uncertain if the ingredients of this lotion are okay or not for rosacea/melasma. It definitely helps rosacea but I worry about if it would help or hurt melasma. Perhaps you might know? The ingredients of this lotion from the bottle are:
Water, Glycerin, Glyceryl Stearate, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Ceteareth-5, Dimethicone, Simmondsia Chinensis (Jojoba) Seed Oil, Aloe Barbadensis Leaf Juice, Panax Ginseng Root Extract, Squalane, Vegetable oil, Glycine Soya (Soybean) Sterols, Soya Liposomes, Tocopherol, Chamomilla Recutita (Matricaria) Flower Oil, Geranium Maculaturn Oil, Allantoin, Ascorbic Acid, Sodium Hyaluronate, Xanthan Gum, Lactic Acid, Beta Carotene, Glycyrrhiza Glabra (Licorice) Root Extract, Retinyl Palmitate, Glyceryl Dilaurate, Citrus Grandis (Grapefruit) Seed Extract, Sodium Cocoyl Isethionate, Potassium Sorbate, Sodium Hydroxymethylglycinate, Phenoxyethanol.
I hope I typed that out right lol. I know for example, that chamomile is good for rosacea and inflammation. As well as licorice. And licorice is good for melasma/discoloration. However, it has Geranium oil, which I've read is a photosensitizer. And it also has liposomes!
I am trying to do the best things I can for my skin right now and I am so confused. I also got some broken capillaries from using a retinol cream for some reason. Sigh |
This cream has a retinoid too (Retinyl Palmitate), so if it was the culprit before you may be at risk again.
If you are looking for some lightening of melasma and decrease in inflammation, I would suggest look for something more emollient and with niacainamide. |
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Sat May 05, 2012 6:56 am |
Thanks for your reply DrJ.  Yes, my skin loves niacinimide. It's in everything I use. My discontinued face cream has it also. I think the broken capillaries must have happened due to using this product along with another retinol cream. As well as extra discoloration. Shoot Well, I'll be sticking to something with niacinimide then. Thanks |
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