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Fri Jun 15, 2012 9:55 am  |
Thank you YB!  |
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Fri Jun 15, 2012 10:09 am |
| I'm young, but I'm already preparing for the epic battle against wrinkles. |
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Fri Jun 15, 2012 8:02 pm |
| I used to buy Life Extension magazine in stores, then subscribed for awhile. It was great to discover I could read it for free online each month! That article covers several things I use...ha serum, resveratol, pomegranate. |
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Sun Jun 17, 2012 4:04 am |
Oh wow, interesting DM!
ErinJoy27, how old are you if you don't mind me asking? I'm going to guess 27?
I must hook up my printer. There are so many great things to print off! |
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Sun Jun 17, 2012 11:46 am |
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to extend life span, impacts mitochondrial function and metabolic homeostasis. Treatment of mice with RSV significantly increased their aerobic capacity, as evidenced by their increased running time and consumption of oxygen in muscle fibers. RSV’s effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in PGC-1alpha acetylation and an increase in PGC-1alpha activity. This mechanism is consistent with RSV being a known activator of the protein deacetylase, SIRT1, and by the lack of effect of RSV in SIRT1(-/-) MEFs. Importantly, RSV treatment protected mice against diet-induced-obesity and insulin resistance. These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis.
Cell. 2006 Dec 15;127(6):1109-22
Noo resveratrol is pro aging due to its effect on slowing the rate of living. The belief that resveratrol is good is based in the entropic "live fast, die young all used up" philosophy which says we better slow down our cells to get more out of 'em. Whole culture has bought this thanks to the massive media campaign. We should not focus on slowing the energy of cells but rather on increasing metabolism.
"The huge marketing campaign for resveratrol will directly affect people’s health adversely, but it is also polluting the culture by reinforcing the doctrine that torpor, slowing the life process, is beneficial." - Ray Peat, PhD
Torpor, you know like a hibernating sloth.  |
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