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Sun Nov 05, 2006 7:53 pm  |
| Hey gang, I saw the thread that is up to some 30+ pages about HA supps plumping lips. I have no clue if this has been gone over in that thread (it will take forever to read through) But I wanted to warn you all that there is a link between breast cancer and high levels of HA. So please be careful and DO YOUR RESEARCH!! |
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Sun Nov 05, 2006 8:40 pm |
| Believe me, since I have dealt with this personally, there is no link that I know of. My surgeon reassured me and I do due diligence. I list every single supplement, injection, vitamin, etc. that I take since I am a nutrional and health nut junkie. Can you show me any research that states there is a link? Is this a personal judgement or based on research? I would be so happy to look into it more if you can tell me what you are basing this on. Thanks. |
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Joined the 50 club several years back, blonde w/ fair/sensitive skin, Texas humidity and prone to rosacea, light breakouts and sunburns, combo skin type, starting to see sundamage and fine lines |
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Sun Nov 05, 2006 8:53 pm |
| Ravenly wrote: |
| ... But I wanted to warn you all that there is a link between breast cancer and high levels of HA. So please be careful and DO YOUR RESEARCH!! |
Its always something, isn't it?  Thanks for the information, its certainly worth looking in to. Oh and welcome to the forum! |
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Sun Nov 05, 2006 9:18 pm |
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2394505&dopt=Abstract
Serum hyaluronan (hyaluronic acid) in breast cancer patients.
Delpech B, Chevallier B, Reinhardt N, Julien JP, Duval C, Maingonnat C, Bastit P, Asselain B.
Centre Regional de Lutte Contre le Cancer Henri-Becquerel, Rouen, Paris, France.
Eighty-three women with breast cancer (57 with systemic metastasis, 26 without) were investigated for serum hyaluronan (HA) and compared to 50 patients with benign diseases of the breast. Hyaluronan was significantly increased in sera of metastatic patients compared to sera of non-metastatic patients (p less than 0.0001) and also in sera of non-metastatic patients when compared to control sera (p less than 0.01). The difference was not related to the number of metastatic sites involved. Three months after starting cytotoxic chemotherapy in metastatic patients, lower HA concentrations were observed in patients responding to chemotherapy. The initial level of serum HA had no predictive value concerning response to chemotherapy.
PMID: 2394505 [PubMed - indexed for MEDLINE]
and also here:
In particular, check out this abstract, from cancer researchers at the University of California San Francisco:
"A hyaluronan-rich environment often correlate with tumor progression, and may be one mechanism for the invasive behavior of malignancies. Eradication of hyaluronan by hyaluronidase administration could reduce tumor aggressiveness and would provide, therefore, a new anti-cancer strategy."
For information on hyaluronidase (an enzyme that breaks down HA) and hyaluronic acid, check out my mitral valve prolapse page.
Women with too low of estrogen levels are at higher risk for conditions like fractures, osteoporosis and a lack of menstruation. Women with high levels of estrogen tend to have increased risks of blood clots, high bone density, high blood pressure and breast cancer. It's not that estrogen is good or bad, it's just that both unusually high levels and unusually low levels are linked to a variety of adverse (and interestingly inverse) health conditions. Perhaps the same may be true for hyaluronic acid.
HA and Other forms of Cancer -
In a paper on hyaluronic acid and colon cancer, researchers wrote that "Hyaluronan (HA) is a cell-surface glycosaminoglycan that has been implicated in cancer progression......These data suggest that HA promotes adhesion to laminin and may thereby facilitate invasion of the basement membrane and metastasis in colon carcinoma."
In another study, researchers found that, "Hyaluronan a high-molecular weight glycosaminoglycan, is considered to be involved in the growth and progression of malignant tumours."
Question: I've read a lot of articles about the benefits of large quantities of vitamin C. Your hyaluronic acid section mentions that ascorbic acid (vitamin C) might be bad for hyaluronic acid. Is vitamin C good to take or not?
Answer: I personally have not had good experiences with taking large supplemental doses of any single nutrient. Every nutrient in the human body has a multitude of co-factors that need to be consumed in balanced amounts for good health, so taking a single supplement may solve one deficiency and then create more problems by triggering co-factor deficiencies.
Vitamin C is a nutrient your body needs in the right amounts. If you don't consume any vitamin C, sooner or later you will develop scurvy, like sailors used to who went on long sea voyages. (British sailors were named "Limies" because of the limes they would take on their voyages to prevent scurvy.) Yet, too much vitamin C, as with too much of any nutrient, can be toxic. Large doses of vitamin C may lower other nutrient levels including vitamin B12, copper and selenium blood levels
I do note a study in my hyaluronic acid section that found that ascorbic acid can degrade hyaluronic acid. But this isn't necessarily bad, in fact for some people, this maybe good thing. While insufficient defective hyaluronic acid isn't ideal, too much HA may not be so great either. High levels of hyaluonic acid have been linked to different types of of cancers, including breast cancer, in a variety of different studies. Interestingly, vitamin C is often mentioned as being beneficial for breast and other cancers.
http://www.ctds.info/hyaluronic_acid_2.html |
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Sun Nov 05, 2006 9:30 pm |
| I guess it was personal in that I would have trouble sleeping at night knowing that I read that info on it and then read that all of these women on here are taking it, potentially unknowingly. Breast Cancer also runs in my family so I, too am very careful what I take. I wasn't intending on bursting any bubbles or starting anything, I just felt a strong urge to let people know that some studies have implicated the link. Take it at what you will. |
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Sun Nov 05, 2006 11:09 pm |
As MermaidGirl said, it's always something
Thanks for posting this Ravenly, it is interesting and I will look into it more.. If there is something to this, I want to know.. BC doesn't 'run' in my family, but my aunt is a survivor.. I had found a lump many years ago, but it was nothing.. But you know it's always on my mind...
If you find anything more, please poet it... |
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Colorful Colorado! Highlands Ranch, a burb south of Denver... |
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Mon Nov 06, 2006 7:44 am |
| Thank you for sharing..was about to purchase some..probably do so..will just take less maybe...will read a little more first.. |
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Mon Nov 06, 2006 7:48 am |
| Is should be personal to share info that may help someone |
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Mon Nov 06, 2006 8:44 am |
| AnnieR wrote: |
| Believe me, since I have dealt with this personally, there is no link that I know of. My surgeon reassured me and I do due diligence. I list every single supplement, injection, vitamin, etc. that I take since I am a nutrional and health nut junkie. Can you show me any research that states there is a link? Is this a personal judgement or based on research? I would be so happy to look into it more if you can tell me what you are basing this on. Thanks. |
Hi AnnieR - I had never heard of this before either so you can imagine how surprised (and disheartened)I was to discover that PubMed does indeed reference studies implicating hyaluronan in human tumour progression. A biochemist I certainly am not - and I certainly can't say definitively what the relationship is between hyaluronan and HA (but I've read that they are interchangeable terms)...but if PubMed (an initiative of NIH and a reputable publisher of health studies) considers it worthy of catalogueing then I certainly think it warrants some attention...I'm certainly going to do my research. If anyone out there knows anything I sure hope you come forward - and thank you to Ravenly for bringing this forward!
Pudoodles |
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Mon Nov 06, 2006 11:29 am |
It IS disheartening 
I was hoping this was my HG for nice plump lips as well |
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Mon Nov 06, 2006 11:33 am |
That's not cool at all!
And now I'm thinking that this might be why I've developed a somewhat-painful nodule in my breast.
Although, when I mentioned my HA-taking to my doctor, she didn't bat an eye. I suppose that most doctors don't know about this yet? |
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Mon Nov 06, 2006 11:55 am |
| Red Devil wrote: |
That's not cool at all!
And now I'm thinking that this might be why I've developed a somewhat-painful nodule in my breast.
Although, when I mentioned my HA-taking to my doctor, she didn't bat an eye. I suppose that most doctors don't know about this yet? |
Gosh - who knows...all I am aware of right now is that hyaluronan seems to be implicated in some of the studies catalogued in PubMed..But we don't know the details or understand the context of the studies...so we shouldn't assume at all that we are necessarily at risk for having ingested HA capsules - we just don't know anything about the study methodologies used, etc...I must admit though that I'm a bit worried for having had it injected into my body (restylane)I'm not freaked out though..but I will look into it more closely! Re: your breast...try not to worry - just see your doc/gyno...I had a sore lump that turned out to be nothing....my doc told me that a painful lump is likely good news and that it is the painless lumps that tend to be more malicious (but see your doc!).....(sigh)I'm still hoping that someone who is well-versed in this area will come forward and put our minds to rest 
Pudoodles |
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Mon Nov 06, 2006 12:03 pm |
| Pudoodles wrote: |
| Red Devil wrote: |
That's not cool at all!
And now I'm thinking that this might be why I've developed a somewhat-painful nodule in my breast.
Although, when I mentioned my HA-taking to my doctor, she didn't bat an eye. I suppose that most doctors don't know about this yet? |
Gosh - who knows...all I am aware of right now is that hyaluronan seems to be implicated in some of the studies catalogued in PubMed..But we don't know the details or understand the context of the studies...so we shouldn't assume at all that we are necessarily at risk for having ingested HA capsules - we just don't know anything about the study methodologies used, etc...I must admit though that I'm a bit worried for having had it injected into my body (restylane)I'm not freaked out though..but I will look into it more closely! Re: your breast...try not to worry - just see your doc/gyno...I had a sore lump that turned out to be nothing....my doc told me that a painful lump is likely good news and that it is the painless lumps that tend to be more malicious (but see your doc!).....(sigh)I'm still hoping that someone who is well-versed in this area will come forward and put our minds to rest
Pudoodles |
Thank you, Pudoodles, you have eased my mind quite a bit! Now I'm glad that I feel that little twinge of pain every now and then! My gyno referred me to a breast specialist, but I am ashamed to say that I am waiting for my company insurance to kick in on December 11. Breast cancer does run in my family, (mother and grandmother), but they both survived and are healthy as horses.
It seems as though everything causes everything these days. If you drink caffeine, you are more likely to suffer from this, if you take too much calcium, you run the risk of that. I've even heard that putting deodorant on your clean-shaven underarms causes cancer!
If there's one thing that my International Affairs minor taught me, that is -- there's ALWAYS a trade-off. |
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American Indian/Irish/African descent, bleach-blonde hair with lowlights, tanned skin, greenish-brown eyes, strong facial features and drastically-improved lips! 28, but people tell me that I look seventeen-ish. |
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Mon Nov 06, 2006 12:07 pm |
Red, my doctor told me that if you drink a lot of coffee/colas/drinks with caffeine in them, sometimes that can cause painful nodules. Its really nothing to worry about, and can be "fixed" if you cut back on that type of stuff.
An old roommate of mine had the problem which was taken care of when she cut back on her coffee intake. Regardless, ALWAYS notify your doctor if you find any type of abnormality in your breast (or anywhere for that matter). If you have a feeling about it and what the doctor says doesn't resonate with you, find a new doctor. |
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Mon Nov 06, 2006 12:20 pm |
The amount of HA that we take to plump our lips - is that an amount that would match the levels found in these women who have breast cancer?
How did these women come to have these high levels of HA naturally? what were the other health factors that brought that about?
Do we know? |
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Mon Nov 06, 2006 12:22 pm |
| MermaidGirl wrote: |
Red, my doctor told me that if you drink a lot of coffee/colas/drinks with caffeine in them, sometimes that can cause painful nodules. Its really nothing to worry about, and can be "fixed" if you cut back on that type of stuff.
An old roommate of mine had the problem which was taken care of when she cut back on her coffee intake. Regardless, ALWAYS notify your doctor if you find any type of abnormality in your breast (or anywhere for that matter). If you have a feeling about it and what the doctor says doesn't resonate with you, find a new doctor. |
That's very true -- there are many doctors out there, some better than others. I didn't like my other doctor very much.
If this turns out to be something bad, I would definitely get a second opinion. Too bad doctors aren't perfect. 
About a year ago I stopped with the sodas and caffeine, and I started taking vitamin E every day, hoping that this would go away, but no deal. 
I will keep you all...er...abreast of what happens. (Somebody please stop me!  )
It's always interesting to me how delicately-balanced our bodies are, and how careful we have to be, especially nowadays, with all of the supplements available to us. |
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American Indian/Irish/African descent, bleach-blonde hair with lowlights, tanned skin, greenish-brown eyes, strong facial features and drastically-improved lips! 28, but people tell me that I look seventeen-ish. |
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Mon Nov 06, 2006 12:28 pm |
Gosh you would think that if there is a correlation between HA and breast cancer than the FDA would not have approved Restalyne. I don't take HA capsules now although I did try a bottle but never found any plumping action for my lips (although my knees felt better.) This is very troublesome and I do hope there is a positive outcome. There has to be a good explanation somewhere..???
Thanks for the post! |
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Mon Nov 06, 2006 1:22 pm |
| Red Devil wrote: |
| ... I will keep you all...er...abreast of what happens. (Somebody please stop me! ) |
HAHAHAHAHAHAHA! You KILL me! You are such a crack up - I saw your reference to the folks at Cynthia Rowland - the "pump peeps" - and about fell on the floor! |
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Mon Nov 06, 2006 1:29 pm |
Glad to entertain!
What did Willy Wonka say? "A little nonsense now and then...is treasured by the wisest men."
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American Indian/Irish/African descent, bleach-blonde hair with lowlights, tanned skin, greenish-brown eyes, strong facial features and drastically-improved lips! 28, but people tell me that I look seventeen-ish. |
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Mon Nov 06, 2006 1:29 pm |
| Lifeplyr01 wrote: |
Gosh you would think that if there is a correlation between HA and breast cancer than the FDA would not have approved Restalyne. I don't take HA capsules now although I did try a bottle but never found any plumping action for my lips (although my knees felt better.) This is very troublesome and I do hope there is a positive outcome. There has to be a good explanation somewhere..???
Thanks for the post! |
Great point re: the supposed correlation! HA occurs naturally in the body ..maybe the point of the studies is just that the mere presence of HA (naturally occurring) serves to somehow support tumorous growth....there is nothing that I've heard of that suggests that HA supplementation can increase cancer risk....perhaps it is just the presence of HA that can be a problem (and therefore puts us all equally at some small risk somehow?)..Anyway,IF there was a risk I'm SURE that someone around here would know (and be able to provide details) |
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Mon Nov 06, 2006 4:11 pm |
| My reading of this is that hyaluran is a matrix molecule that cancer cells use - they probably produce it in order to invade tissues. I don't see HA increasing the likelihood of cancers or the growth of cells. This will sound very glib but as I see it, cancer cells grow fast and use proteins so it would be tanatmount to saying that eating a lot of protein is associated with cancer. I may have missed the point altogether and I hope I'm not causing any offence. I guess I'm hoping I can keep taking my HA caps and sleep in peace... |
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brasscupcakes
New Member
 
Joined: 15 Oct 2007
Posts: 9
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Sun Oct 21, 2007 11:33 pm |
It was in the New York Times -- was only a few sentences at the end of an article about beauty applications and it didn't mention breast cancer specifically, but we've always got cancer cells traveling around our bodies that the immune system is supposed to take care of and I'd rather see mine sluggish.
I mean, transit is basically the same thing as metastasis, isn't it? |
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Wed Jun 19, 2013 11:26 am |
this does not make sense given that
Experiments show that hylauron highly available in naked mole-rat cells, allow the rodent to be "cancer-proof".
http://www.bbc.co.uk/news/health-22961694 |
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