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Tue May 13, 2014 12:44 pm  |
I want to make my own hair darkening lotion based on a melitane ( acetyl hexapeptide) study. A seller on ebay selling the pure melitane recommended me to use 45 pct water, 30 pct ethanol, 20 pct PG and 5 pct of melitane.
OR: I could use a PH neutral shampoo. Personally I have my doubts about the fact that 5 minutes exposure time of shampooing could have the same kind of impact.
Now the thing is: I would also want to use it as a eyelash darkening lotion but I'm afraid it's not a good idea adding the ethanol. Do you know about something that could replace ethanol with the same penetrating compounds ( and gentle for the eyes, hair, surrounding skin)
Many thanks in advance
Here's the study:
Research in Pharmaceutical Sciences, 2012;7(5)
School of Pharmacy and Pharmaceutical Sciences
Isfahan University of Medical Sciences
S64
Maidenhair shampoo and hair lotion: Dermatopharmacological
and dermatotoxicological evaluation
S. Fatemi1,*, A. Jafarian Dehkordi1, A. Ali Ghanadi2, M. Babajani3, Z. Banaei4
1Department of Pharmacology, Pharmacy Faculty , Isfahan Uuniversity of Medical Science, Isfahan, Iran
2Department of Pharmacognosy, Pharmacy Faculty , Isfahan University of Medical Science, Isfahan, Iran
3 Physical Chemistry Branch of R&D Lab. of Goltash Company, Isfahan, Iran
4 Biology Branch of R&D Lab. of Goltash Company, Isfahan, Iran
Background and Aims: Melanogenesis, the process of synthesizing melanin, is controlled by a variety
of molecular pathways, including signaling through the melanocortin type 1 receptor (MC1R). Binding
of α-melanocyte stimulating hormone (α-MSH) to MC1 Receptor leading to an increase in the activity
of enzymes involved in the production of melanin pigments. The present study was designed to
explore the stimulation of melanogenesis and anti- graying effects of Adiantum capillus-veneris
(Maidenhair) and Melitane (a biomimetic peptide agonist of α-MSH) in their lotions.
Methods: Dermatotoxicological Effects of shampoo and hair lotion was studied by RBC (Red Blood
Cell), Zein, Skin Drize and human patch tests. For studying of dermatopharmacological Effects of hair
lotions, containing A) Propylene glycolic extract of maidenhair B) Melitane C) Maidenhair and
Melitane D) Benchmark (Phyto), a half head test method was used with 60 men in 4 groups with gray,
white and black hairs. The application of shampoo and lotion was made according to the test, one half
with 2.5 g shampoo and then 4 ml lotion containing active matter and the other half with control
shampoo and lotion without active matter. The application was continued for 3 months, one time in a
day. White hair was counted prior and 3 months after lotion application, using a shablon.
Results: White hair average for lotion containing Melitane considerably is decreased in comparison
with control lotion. This effect is not seen for Maidenhair lotion. Based on results of
dermatotoxicological tests, all lotion was without side effects for eye and skin and all shampoo was
mild irritant (similar to other mild shampoo in the market).
Conclusions: These findings confirm that Melitane is a melanogenesis stimulator and exhibits antigraying
property. But the products were made just by Maidenhair extract had no anti- graying effect.
Keywords: Shampoo; Lotion; Adiantum capillus-veneris; Hair graying |
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Thu Jun 12, 2014 3:41 am |
| Thank you so much. I received the formula for melitane. They recommended me 10 ml melitane 10 ml dimethyl isosorbide as a carrier and 180 ml water to have maximum results. |
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| Sat Nov 30, 2024 11:49 pm |
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