Lipo-filling (FAT) stimulation action on topicals
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free skin care · Sun Apr 18, 2010 7:36 am

I have been researching the claims some products made on increasing subcutaneous fat after accidentally finding that on Cp's:

Extract from: http://www.reverseskinaging.com/tighten.html

Quote:

As Copper-peptides help tighten skin, they also improve healthy fat volume by increasing increasing the subcutaneous fat layer (baby fat).

I have not found many user's of CP's backing up this state other than Alexes post on the CP's thread.

However I kept researching and found some stuff on the net claiming the application of some topicals leads to an increase of adipocytes (sub cutaneous fat). Most of them are addressed to breasts or buttocks, but interesting enough I have found references to the same products could be used on hands and cheeks:

Lab. Sederma -the labs who made matrixyl 3000- has a new active called VOLUFILINE:

http://truthinaging.com/face/dept-of-daft-rodial-boob-job/

Quote:

...It is called Volufiline and it is made by cosmetics ingredients company Sederma. Volufiline is, in fact, the combination of hydrogenated polyisobutene, a synthetic oil that is widely used in cosmetics, and root extract of the anemarrhenae asphodeloides plant, a laxative that is also used to make soap. Unlikely as it may seem, this combination is good at stimulating the adipocytes, the connective tissue that makes and stores fat.

http://www.sederma.fr/Actives/Volufiline.htm

Quote:

This, non hormonal, treatment stimulates adipocyte differentiation, proliferation and volume in order to bring volume where it is needed

http://www.crodausa.com/html_product_sheets/SedfeatureVolufiline.htm

Quote:

Clinically tested, VOLUFILINE increased the bust volume of small breasted women. VOLUFILINE is also recommended to help plump the buttocks, hands, cheeks and any other part of the body or face that needs volume filling.

IN VITRO EVALUATION OF VOLUFILINE
Adipocytes
 Cell volume increased over 22 times!
 Lipid storage increased more than 600%!
Pre-adipocytes
 Cell differentiation increased by more than 200%!

CLINICAL STUDIES SHOW INCREASE IN BREAST PLUMPING AFTER VOLUFILINE APPLICATIONS
 Enlargement after 56 days reached as much as 8.4%!
Non-Warranty: The information in this publication is given in good faith by Sederma® by way of general guidance and for reference purposes only.

I wonder about independent studies over this... All what I have found is from Sederma...

This site does not says what is the active ingredient in its formulation, but has good graphics to check. I suspect the active is the same one from sederma, volufiline:

http://www.provital.com.tr/english/index.php?konu=actibreastdet

Quote:

The effect of the patented active component over adipocyte (fat cells) is proved by scientific experiments.

Phytosterol with no hormonal activity:
- Stimulates adipocyte proliferation and differentiation.
- Promotes lipid storage.
- Increase of adipocyte volume in the fatty tissue.
- Can be applied on breast, buttock, hands o]r cheeks.

Hi have found this DIY ebay seller (sort of skin actives) who formulates and sells its own products. This one is formulated as a bust serum but the ingredients list looks very good to me. I want to contact the seller and ask if he has any experience with this product used on other areas of the body as hands:

http://cgi.ebay.com/ws/eBayISAPI.dll?ViewItem&item=370293223214#ht_2305wt_939

Quote:

Forever Young 'Aumenti' Bust Enhancement and Firming Lotion
Here are the active ingredients
Bio-Bustyl® contains two complimentary biopeptides that stimulate collagen synthesis and replenish the elastic properties of the skin to firm the body and breasts. Bio-Bustyl® has been shown to be effective to firm loose or sagging skin resulting from weight loss, childbirth, nursing or natural aging.
In clinical studies Bio-Bustyl® is shown to:
 Increase skin firmness by +18.5%
 Increase tone by +13%
 Reduce skin fatigue by 16.5
 Stimulate collagen synthesis by as much as 350%.
Volufiline®.is a remarkable product that increases the volume of tissue by increasing the amount of fat cells in particular areas (the area to which Volufiline is applied) and increasing the volume of fat in these cells by up to 22%. In tests on women between 18 and 35 with a cup size between 30A and 34AA applied a cream containing 5% Volufiline to one breast for 56 days. On average the treated breast tissue increased in volume by up to 8.4% over the untreated breast.
Vexel® combines caffeine with palmitoyl-carnitine to help improve tone, firm, restore elasticity and reduce slackening of skin especially for the stomach, arms and décolleté. In Clinical Studies panelists who used Vexel TM for 28 days reported that the skin was more toned by 73%, firmer 78%less slack 85%.
The three actives above are manufactured by Sederma - the company that developed the famous Matrixyl, Eyeliss, and Haloxyl active ingredients

Tri-peptide 5 - a peptide with the ability to penetrate deep into the skin to work within the dermis itself. Tri-peptide is so effective that clinical research shows that it can even repair the damaged collagen and elastin bundles that create stretch marks. This active is included in our lotion for one simple reason - if collagen and elastin fibres within the dermis can be strengthened then the breast will have better support and lose some of that 'droop'

The active ingredients are carried in lotion that is designed to support the role of the active ingredients. The lotion contains Emu Oil, highly regarded for its ability to penetrate the skin and carry active ingredients with it, and Rosehip oil which has been used traditionally for hundreds of years to improve the skin - especially in its ability to improve stretch marks. The base lotion contains high levels of Vitamins D and E, and significant levels of Vitamin A and C, all of which are wonderful for the skin.

Lierac has Lipofilling Correction Volumes Cream and lipofilling nuit.
This one is addressed specially for the face:

http://www.lierac.com/UK/products/face/anti-aging/lipofilling-deepliftanti-agingcream-volumecorrection/lipofillingnuit-intenseregeneratinganti-agingcream.html

Quote:

[size=18]Rich and ultra-comfortable, this regenerating cream acts during the night when skin cells are most receptive. Combined with the volumizing complex exclusive to LIERAC, an Asian plant extract helps increase the size of adipocytes**Cells capable of storing fat to preserve facial volumes. and boost their multiplication. Enriched with lavender essential wax, sweet almond, althea and linseed, this cream provides targeted nutrition. Night after night, facial volumes appear rebalanced, the features seem “lifted”, the skin feels denser and more elastic.

I don't get this: What do they mean about "cells capable to storing fat to preserve facial volumes"???? good back up for the company...
So if doesn't work for me is because my cells can't store fat? or are they telling you do not put it on your lashes, 'cause lashes cells are unable to store fat Confused

...

Other products containing this type of active/s:

-MOSBEAU SUPERB BUST & BUTT ENHANCER

-Pupa Breast Enhancer Intensive Treatment

-Rodial Boob Job

Do you know of any other active/ingredient with lipo-filling action?
Have any of you tried any of these products?
What do you think? Question

free skin care · Sun Apr 18, 2010 9:22 am

More findings:

http://www.entrepreneur.com/tradejournals/article/169162613.html

Quote:

Kombuchka is the trademark of a cosmetic active version of kombucha that is intended to produce a lipofilling effect upon topical application.

According to Dr. Zoe Draelos, this substance is high in organic acids and B vitamins, and includes glycerin and hydroxyethylcellulose. It is said to exert a cosmetic effect by hindering glycation and augmenting cultured fibroblast factors to further adipocyte maturation, thereby expanding subcutaneous fat on the face and hands.

Dr. Draelos notes that skin smoothness is the clinical test used to evaluate the level of lipofilling and, importantly, moisturization and exfoliation can confound such a determination ("What is the difference between spa line and cosmetic counter skin care products?" Cosmetic Conundrums, Dermatology Times, Nov. 1, 2004).

Revercel PM combines palmitoyl oligopeptide (Dermaxyl) and diacetyl boldine (Lumiskin), the latter is a potent antioxidant derived from the bark of a tree that grows in the Chilean and Peruvian Andes.

The product also contains Kombuchka, along with botanicals such as jojoba esters, apricot kernel oil, sunflower seed oil, and shea butter. Revercel PM is designed to restore tone, volume, and healthy color to the skin, and reduce the appearance of lines and wrinkles.

Kombuchka is also used in Global Beauty Anti-Ageing Radiance Cream, which was created by Dr. Laurent Miralles. He claims that his 3% concentration results in an increase in collagen cells and adipocytes that expand skin volume

Kombucha shows promise, but much more work is necessary to determine whether this popular compound can confer dermatologic benefits.

.

A patent pending extract:

http://www.faqs.org/patents/app/20090010976

Quote:

13. The method of claim 1, further comprising an agent useful to stimulate subcutaneous lipid synthesis.

[0015]The invention being the subject of this patent application also relates to a product which allows mimic the plastic surgery. The aim is to make a cosmetic "lipofilling" by carrying out a cutaneous filling by increasing the adipocyte mass, which, being newly formed by the organism itself, will gum or reduce the importance of the wrinkles while ensuring a perfect tolerance and painless to the consumer. The principle of this cosmetic lipofilling is the stimulation of the lipids synthesis by cutaneous adipocytes. These effects were studied and shown, in vitro and in vivo, and will be clarified in the examples given in this patent application.

[0034]We also observed and showed that kombucha, by topical application, makes it possible to carry out a cosmetic "lipofilling"

http://www.creative-developments.co.uk/papers/Skin%20Care%202006.pdf

Quote:

Pulpactyl provides a lipofilling effect by stimulating adipogenesis and the swelling of fat cells

free skin care · Sun Apr 18, 2010 12:19 pm

I think the rye extract in Osmotics Lipofill Non-Surgical Filler is supposed to have this action.
I haven't used it so I don't know if it has any effect.

free skin care · Sun Apr 18, 2010 4:18 pm

Thanks Brierose

Now this article is VERY interesting...
Talks about using retinoids (a form of a retinoid)and decreased fat on an study performed on rats. It also mentions Vit A ingested leads to decrease body adiposity:

http://resources.metapress.com/pdf-preview.axd?code=676x51826013l203&size=largest

Another reference about the use of Vit A topically to decrease fat (used to treat cellulite):

http://www.spa20-20.com/articles/541feat1.html

Quote:

Topical retinoic acid and related vitamin A derivatives have been used to stimulate circulation, decrease the size of adipocytes and increase collagen deposition in the dermis.

Doesn't make you think about your face? I am using tretinoin (vit A) right now! lol!

free skin care · Fri Apr 23, 2010 4:43 pm

I have found another -apparently- enemy of fat: White tea

Quote:

For a 2009 study, researchers tested white tea's anti-obesity effects in a series of experiments on human fat cells. Results showed that white-tea extract prompted fat to break down in existing fat cells. What's more, white tea seemed to reduce the expression of genes crucial to the growth of new fat cells.

While the study's authors suggest that white tea may be "an ideal natural source of slimming substances," scientists have yet to explore whether the tea could fight obesity when sipped (rather than administered directly to cells in a lab).

Also:

Quote:

Topically applied white tea may improve the immune function of skin cells and protect against harmful ultraviolet rays, a 2003 study suggests. It should be noted that the study was funded by the skin-care company Origins Natural Resources, which manufactures white-tea-based products.

From: http://altmedicine.about.com/od/herbsupplementguide/a/whitetea.htm

I've thought those of you using white tea pre led treatment would find this interesting.

free skin care · Fri Apr 23, 2010 4:59 pm

Zenity wrote:

I have found another -apparently- enemy of fat: White tea

Quote:

For a 2009 study, researchers tested white tea's anti-obesity effects in a series of experiments on human fat cells. Results showed that white-tea extract prompted fat to break down in existing fat cells. What's more, white tea seemed to reduce the expression of genes crucial to the growth of new fat cells.

While the study's authors suggest that white tea may be "an ideal natural source of slimming substances," scientists have yet to explore whether the tea could fight obesity when sipped (rather than administered directly to cells in a lab).

Also:

Quote:

Topically applied white tea may improve the immune function of skin cells and protect against harmful ultraviolet rays, a 2003 study suggests. It should be noted that the study was funded by the skin-care company Origins Natural Resources, which manufactures white-tea-based products.

From: http://altmedicine.about.com/od/herbsupplementguide/a/whitetea.htm

I've thought those of you using white tea pre led treatment would find this interesting.

I wish it would work on the pooch under my chin. You've given me an idea though. I'm going to start adding white tea to my bath water. Laughing

free skin care · Fri Apr 23, 2010 9:22 pm

Zenity, this is a very interesting thread. You always come up with thought-provoking info!

free skin care · Sat Apr 24, 2010 12:22 am

LOL! Bethany, You just made me think...

I had one teacher at school who used to tell me the same thing... I wonder if it was a postive comment or a negative one...No kidding she didn't like all my comments and questions. I used to spend her classes at the hallway if I opened my mouth more than 3 times. She used to complain about me 'cause I was inducing the other kids to "think too much"

free skin care · Sat Apr 24, 2010 7:09 am

Increases in body fat come via the metabolic cycle, so claims that topicals could influence this process seem??

BF

free skin care · Sat Apr 24, 2010 11:48 am

Zenity wrote:

LOL! Bethany, You just made me think...

I had one teacher at school who used to tell me the same thing... I wonder if it was a postive comment or a negative one...No kidding she didn't like all my comments and questions. I used to spend her classes at the hallway if I opened my mouth more than 3 times. She used to complain about me 'cause I was inducing the other kids to "think too much"

Mine was definitely a positive comment! Very Happy

But I bet you were probably causing HER to think too much too, lol.

free skin care · Sat Apr 24, 2010 1:38 pm

Barefoot girl,

I don't know a lot about fat itself, other than how to treat cellulite and how to get some fat on my face and chest... LOL! But I know there are different types of fat. The ones we want to address here are the subcutaneous type, the pads under your skin in body areas where they are suppossed to be (face, boobs, bottom etc)and we keep loosing due to aging, dieting, sport, hormones etc.
I think this actives are meant to work on those areas better as they are more receptive to get some fat than fingers, for an instance.

------------------

Beth, now that you mention it I think I was probably giving her a bit of headaches at the time... Always questioning everything! LOL!

free skin care · Sat Apr 24, 2010 5:41 pm

An ingredient found in lip plumpers called "amplifat" claims to stimulate and increase fat.

Amplifat is an extract from an algae:
dictyopteris Membranacea Extract

And, according to this site:

http://envisk.com/references.asp?refID=37&abb=dictyo

This is what it does:

Quote:

Dictyopteris Oil stimulates 3 essential proteins involved in the nutrition of adipocytes:
Fatty Acid Transferase (FAT): expressed on the surface of adipocytes, it facilitates the transport of fatty acids inside the cell.
Adiponutrin: this adipokine promotes the storage of triglycerides by adipocytes.
Perilipin: this protects the lipid droplets contained in adipocytes from lipolysis.
The stimulation of these 3 proteins promotes the capture of lipids by adipocytes
for a tissue nourishing action that restores volume.

free skin care · Sat Apr 24, 2010 5:55 pm

Another one.

Voluplus

From:
http://www.centerchem.com/Capability.asp?CapabilityID=3583&Cat1ID=20 Samples avalaible???

Quote:

Voluplus™ is a natural active ingredient which is proven to increase the density of adipose tissue, causing a significant and noticeable volumizing effect. This cosmetic product contains a natural active ingredient from nutmeg (Macelignan) solubilized in macadamia oil. It increases breast volume and improves femine curves, acting naturally and safely on cells which retain corporal fat, leading to a superior breast development. Recommended concentration: 2-5%.
INCI Name: Macadamia Ternifolia Seed Oil, Macelignan.

--------------------------------

At smartiskincare there is a thread where I have found the info about the 2 last actives listed here.

--------------------------------

Well, from all my research, topicals are being designed to help subcutaneous fat... But the question is still in the air: DO THEY WORK?

I may be able to test some in the next months...

I know this is getting boring, but thanks to let me take my notes at this space. Having all of this posted helps me out to organize information and, who knows, maybe, help others as well.

Sat Apr 24, 2010 8:37 pm

Hi!
I don't find it boring at all! I am anxious to see what you discover. I would love to build up fat in my lower face, hands, and breasts!

Thank you for sharing Smile

free skin care · Mon May 03, 2010 8:50 pm

I really doubt any of these products can reach the hypodermis.

For e.g....

Toxicity studies reported that Volufiline (hydrogenated polyisobutene +nemarrhenae asphodeloides), absorption, so if it barely reaches the dermis, how on earth is it going to reach the hypodermis?? Does the cream come in premeasured syringes? Laughing

In addition, a recent research paper found antiadipogenic properties Rolling Eyes

free skin care · Mon May 03, 2010 9:02 pm

Zenity wrote:

Another one.

Voluplus

From:
http://www.centerchem.com/Capability.asp?CapabilityID=3583&Cat1ID=20 Samples avalaible???

Quote:

Voluplus™ is a natural active ingredient which is proven to increase the density of adipose tissue, causing a significant and noticeable volumizing effect. This cosmetic product contains a natural active ingredient from nutmeg (Macelignan) solubilized in macadamia oil. It increases breast volume and improves femine curves, acting naturally and safely on cells which retain corporal fat, leading to a superior breast development. Recommended concentration: 2-5%.
INCI Name: Macadamia Ternifolia Seed Oil, Macelignan.

I just found a patent application that uses Maceligan to lose weight because it says it accelerates fat decomposition

METHOD FOR PREVENTING AND TREATING CONDITIONS MEDIATED BY PPAR USING MACELIGNAN

It's crazy!

free skin care · Tue May 04, 2010 3:14 am

LOL! it sounds crazy! I need to research a little bit more on this.
Still waiting for the volufiline to arrive. Can't wait to try it...

free skin care · Tue May 04, 2010 4:26 am

Josee wrote:

I really doubt any of these products can reach the hypodermis.

For e.g....

Toxicity studies reported that Volufiline (hydrogenated polyisobutene +nemarrhenae asphodeloides), absorption, so if it barely reaches the dermis, how on earth is it going to reach the hypodermis?? Does the cream come in premeasured syringes? Laughing

In addition, a recent research paper found antiadipogenic properties Rolling Eyes

The slings and arrows of outrageous claims....... hmm

free skin care · Tue May 04, 2010 4:55 am

In the meantime kombucha sounds like a good one.
It is natural and have been reported to work as a topical for its lipo-filling effects.

free skin care · Tue May 04, 2010 5:02 am

Well, I guess dry skin brushing, dermarolling or galvanic could help with absorption. Which is something that I do regularly to make sure i get the most of any topical...
For the rest, I really think this subject of topicals increasing adipogenesis is so new that a lot more research has to be done before making the claims the manufacturers do...

As I haven't found those studies from independent resources or any reviews or following ups from actual users I guess I will play the guinea pig for a while...
I won't use it on my face but other parts of my body and hopefully "something" will happen...

Josee wrote:

I really doubt any of these products can reach the hypodermis.

For e.g....

Toxicity studies reported that Volufiline (hydrogenated polyisobutene +nemarrhenae asphodeloides), absorption, so if it barely reaches the dermis, how on earth is it going to reach the hypodermis?? Does the cream come in premeasured syringes? Laughing

In addition, a recent research paper found antiadipogenic properties Rolling Eyes

free skin care · Tue May 04, 2010 5:03 am

Zenity wrote:

In the meantime kombucha sounds like a good one.
It is natural and have been reported to work as a topical for its lipo-filling effects.

I will be interested in hearing what your results are! Smile

I hope it works for you.

free skin care · Tue May 04, 2010 5:10 am

DarkMoon wrote:

I will be interested in hearing what your results are! Smile

I hope it works for you.

I will post my findings, no worries.

At least I am happy I have found one way to increase my facial tissues including fat that works. But as always sounds so cool to find the magic potion in a jar that doesn't require a lot of work that I am prone to fall for these type of promises... But! before a lot of research has to be done to determine if is worth a try or not...

Silly me! Laughing

free skin care · Sun Jun 06, 2010 5:06 am

any progress?

free skin care · Wed Jun 09, 2010 5:34 pm

Yep,

Volufiline works. I've been using it 3 times at day on decollete, hand, knee, elbow, temples, cheek, buttock and forearm only one side of my body (the left one) for 3 weeks now.
The product I've used is ad as a bust enhancer, so it has other actives on it and I am not sure about percentages, also is the cheapest one I could find online.

While on my bony parts as temple elbow and knee have not noticed a significant change, yet, I have to report that in my decollete, forearm and buttock is working. I feel more density under my skin and it feels thicker when I pinch it.

Nothing has change in my cheek in reference to the other one, I wonder if it has to do with my facial exercises routine and the massages... I am planning on taking a break from manipulating my face and see how it goes.

My early conclusion is that Volufiline works better on areas that are prone to have natural fat storage as breasts, belly, hips and derrier, while for bony parts on our body a general increase in fat would be needed to fill them up.

I am planning to keep using it until I ran out of my bottle and try something different next.

Will let you know.

Anyone else experimenting?

free skin care · Fri Jun 11, 2010 9:20 am

Hi Zenity,

Where did you buy it?

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