DMAE question
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Fri Mar 28, 2008 6:41 pm

There was this article:

Anti-Wrinkle Compound Causes Pathological Reaction In Skin Cells

Researchers from Université Laval's Faculty of Medicine have discovered that a compound commonly used in many antiwrinkle products causes a pathological reaction in skin cells. Guillaume Morissette, Lucie Germain, and François Marceau present their conclusions about the mode of action of this substance - called DMAE - in the latest edition of the British Journal of Dermatology.

DMAE (2-dimethylaminoethanol) is used in many antiwrinkle products dubbed "instant anti-aging face-lifts." This compound, as well as other chemically similar ones, are also found in cosmetics, creams, lipsticks, shampoos, soaps, and baby lotions, although the way they work is not yet understood.

The rest of the article can be found here: http://www.medicalnewstoday.com/articles/67643.php

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BACKGROUND: The 'cosmeceutical' agent 2-dimethylaminoethanol (DMAE) is a tertiary amine found in high concentration in numerous topical antiwrinkle preparations. OBJECTIVES: We hypothesized that a 337 mmol L(-1) (3%) DMAE reservoir applied to the skin could reproduce the cytopathology induced by other amines by maintaining a millimolar drug concentration within a certain depth of the skin layers, and that vacuolar cell expansion could account for the very rapid effect on the apparent skin fullness. METHODS: Morphological and functional assays were applied to cultured rabbit dermal fibroblasts treated with tertiary amines in vitro. A morphological verification of the vacuolization caused by topical DMAE was also attempted in vivo using the inner skin of the rabbit ear and in vitro using primary cultures of human cutaneous epithelial cells. RESULTS: Fibroblasts responded to DMAE (2.5-10 mmol L(-1)) by massive vacuolization (0.5-4 h; phase contrast observations). Triethanolamine, another chemical frequently used topically, was also active in this respect (10 mmol L(-1)). The vacuolar adenosine triphosphatase inhibitor bafilomycin A1 prevented DMAE- or triethanolamine-induced vacuolization; adding bafilomycin A1 or cell washout slowly reversed the established vacuolization induced by DMAE. Further effects of DMAE in cultured fibroblasts included a moderate cytotoxicity (10 mmol L(-1)) that was abated by bafilomycin A1 cotreatment, a concentration-dependent mitotic arrest (2.5 mmol L(-1)) and transient and mild effects on cell ploidy. The epidermis of the rabbit external ear was significantly thickened and exhibited clear perinuclear swelling indicative of vacuolization in response to 3% DMAE (1 h; paraffin tissue sections). Cultured human cutaneous epithelial cells responded to DMAE by vacuolization (inhibited by bafilomycin A1 cotreatment). CONCLUSIONS: The vacuolar cytopathology induced by concentrated organic amines may be the cellular basis of the antiwrinkle effect of DMAE.
http://www.ncbi.nlm.nih.gov/pubmed/17300230?dopt=AbstractPlus

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More discussion on EDS....

http://www.essentialdayspa.com/forum/viewthread.php?tid=22612

http://www.essentialdayspa.com/forum/viewthread.php?tid=22980&highlight=dmae

http://www.smartskincare.com/forum/viewtopic.php?t=2820

free skin care · Sat Mar 29, 2008 10:43 am

Lou, just do a little more research. Keep in mind that topical DMAE is fairly new to the cosmetic industry, so nothing difinitive is really known at this point for long term use.

The 'animal' studies for topical application suggest that the cell membrane is damaged by DMAE from the inside out, and cell death is the result. On the other hand, lots of 'humans' have had the tightening effect from it, and that's hard to dispute. The problem people are running into now, is that once they stop or cut back on the topical DMAE, some are noticing 'more' sag than before they started the treatment. Which to 'me' suggests that the damage done, is not apparent immediately.

I along with so many others heard about the wonders of DMAE, and ran out and bought both the topical cream and internal supplement. Only then did I do some research, and decide that 'for me' it wasn't worth the risk. I gave the cream away, but take a supplement occassionally (one or two per week).

This is just my feelings about it Lou, I'm sure there are many others who are using it without ill effect, and would recommend it. Like everything else, it all comes down to each individuals personal experience. For some things work, for others not so much.

For me, the little nurse voice is telling me it's not worth the gamble.

Kassy

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