Has anyone tried Re Vive?
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free skin care · Mon Nov 15, 2004 8:12 pm

Hello guys
just got a few samples of the C booster and i just love it. ..it says it's the most stable form of Vit.. C i know that alot of there product Have EGF.. and the $600 serum has KGF..(helps turn over cells 8 times faster) has anyone one used this line before....?

free skin care · Mon Nov 15, 2004 8:38 pm

Oh my $600.00. I don't think I ever will be trying that. I could see it now. I go out and buy it and it doesn't deliver for me. Talk about depression.

For anyone who has tried it I certainly would love to hear your reviews.

Winnie

free skin care · Sat Apr 22, 2006 11:24 am

Again I don't think your KGF is the exact same KGF used by the Revive Laboratories. Revive's line is expensive b/c it exp to reproduce HUMAN growth factors. Not so expensive to do from plants as others do and skin actives as well.

Ladies don't be fooled by the same name. Growth factors such as EGF and KGF can be reproduced but from plants not humans and there is a difference.

free skin care · Sat Apr 22, 2006 11:41 am

My understanding is that the only products using human recombinant growth factors are SkinMedica's TNS line, the ReVive line, and the Neocutis line.

Sat Apr 22, 2006 11:54 am

Wenrwdy,
EGF has been around for a pretty long time. In 1986, Stanley Cohen received the Nobel Prize for his work elucidating the role of the Epidermal Growth Factor (EGF) in the regulation of cell growth and development.

EGF is manufactured by a number of labs around the world that supply the medical and cosmetics industries.

Our EGF is made by world class scientists in the same way that ReVive and others make theirs. Please visit our site for references and customer reviews.

free skin care · Sat Apr 22, 2006 12:06 pm

although the TNS serum has the KGF in it, it may not be the best way of using it.

Someone I know had actally emailed Dr. Brown (of ReVive) and my understanding of his opinion was the TNS was too risky to use; I believe he felt that no one really knew exactly what was in the growth factor "soup" called Nouricel, and that it may indeed contain adverse factors along with the helpful ones.

So I am sticking with the Revive serum forever. Growth factors in too large quanities may also have adverse effects and trying to do it yourself is not such a good idea. The scientists at Revive Labs know what they are doing when they formulate this and I would not trust just anyone or myself w/o the knowlege they have. Fromualtion is soooo important and ingreidents to help actives penetrate better and how much of each is also important. Won't trust just anyone with that either.

also another ingredient in the serum is the Tri-Whitening complex to lighten spots and it is considered one of the safest on the market. It is also SUPER exp to produce and no doubt is factored into the price.

so point being, just b/c someone else says they have the same "active" in the other reputable products doesn't mean you'l get the same results concocting your own for a fraction of the price.

I've learned in life, "you get what you pay for"

Sat Apr 22, 2006 12:18 pm

I completely agree that formulation is really important and that if you have found a product that works for you you should definitely keep using it.

Our products are not for everyone, but they are very safe, the results are excellent, and the pricing is much more affordable.

free skin care · Sat Apr 22, 2006 12:21 pm

I am aware of the history of it and it was Dr. Brown of Revive who won the Nobel Peace Prize in 1986 for applying the bioengineered version of EGF into skincare.

From reviveskincare.com: The discovery of EGF went on to win a Nobel Prize in 1986. His findings were published in the New England Journal of Medicine in 1989. He won the cosmetic patent for EGF in 1994. Through perseverance, Dr. Brown realized his dream and launched RéVive to the public in 1997."

and you still have not answered my question on the source of your EGF.

free skin care · Sat Apr 22, 2006 12:34 pm

I have tried quite a few items in the Revive line. The only one I would repurchase so far is the Volumizing serum. If you check ebay, you can get really good deals, I got mine for about half the retail price. I had a sample first from the revive website, and it is the same product that I received off of ebay, sealed as well (if anyone is worried about authenticity of the products sold on ebay). hths.

Sat Apr 22, 2006 1:01 pm

Our growth factors are made through biotechnology in the same way the ReVive makes it. It is the only way that EGF and KGF are made in the modern era.

Step 1: many people have already worked very hard to find the amino acid sequence of the growth factor. From this sequence of amino acid a scientist works out what nucleotide sequence will tranlate into THAT amino acid sequence

Step 2: by several steps (several little pieces of DNA are synthesized chemically, the pieces are put together in the right sequence with the help of special enzymes), the scientist obtains a piece of DNA with the right sequence of nucleotides. The sequence has to be checked and re-checked, otherwise everything that comes afterwards is a waste of time

Step 3: the piece of DNA, designed as per steps 1 and 2 is inserted inside a piece of DNA, called plasmid, that has the right structure to be duplicated by a bacterium or yeast cell.

Step 4: the plasmid, now containing the piece of DNA that "codes" for our growth factor, is inserted in a bacteria or yeast.

Step 5: the cells containing the plasmid are cultured and at a certain point, a chemical order is given to the cells to start making the growth factor (or whatever is coded in that plasmid)

Step 6: the cells, full of our protein (sometimes as much as half of the total protein) are removed from the liquid medium, and broken to release the contents.

Step 7: the protein of interest is purified from the other "stuff" by a series of protein purification methods.

Step 8: the pure protein is precipitated in a concentrated ammonium sulfate solution to preserve the integrity and activity of the protein.

It is not an easy process and it takes dozens of years of experience in the process and about a year to confirm the sequence of the protein.

free skin care · Sat Apr 22, 2006 1:04 pm

I'm not criticizing Revive products, but FOR THE SAKE OF ACCURACY:

It's true that the 1986 Nobel prize for physiology & medicine was won for the discovery of EGF & NGF. HOWEVER, Brown was not the winner of the prize.

Press Release: The 1986 Nobel Prize in Physiology or Medicine
NOBELFÖRSAMLINGEN KAROLINSKA INSTITUTET
THE NOBEL ASSEMBLY AT THE KAROLINSKA INSTITUTE
13 October 1986

The Nobel Assembly at the Karolinska Institute has today decided to award the Nobel Prize in Physiology or Medicine for 1986 jointly to

Stanley Cohen and Rita Levi-Montalcini

for their discoveries of "growth factors".

Anyone who is interested in a summary of the discovery by Cohen and Levi-Montalcini and just go ahead and Google it. I didn't want to take up more room than was necessary here.

I took a look at Brown's book. He repeatedly makes very misleading statements. He very craftily notes that the '86 Nobel Prize was awarded for the discovery & development of EGF AND he words it in such a way as to lead the reader to believe that it was awarded to HIM. He also mentions his patents as though they were given to him as prizes or awards. Anyone can file a patent request for a product for a relatively small fee. In Brown's case, he filed patents for Revive products - it's a standard business practice. He does NOT hold a patent on EGF as a primary substance.

If the products work for people, I think that's fabulous. I just get so damn annoyed when the developer or marketer of a particular product makes statements that are purposely misleading or when they try to frighten people away from other products. There is NOTHING dangerous about the TNS Recovery Complex. Ironically, there are legions of dermatologists who swear by it. I've yet to see one (who wasn't paid for the use of their name, that is) who recommends the department store brand Revive.

free skin care · Sat Apr 22, 2006 2:03 pm

You're right Katee.

This is exactly how it is worded:
"Dr. Brown was the first doctor and scientist to apply the bioengineered version of EGF into skincare. The discovery of EGF went on to win a Nobel Prize in 1986." It does not say that he went on to win it.

I stand corrected. And you're right they should not imply that he won it. A Revive rep had acutally told me that he won it. And I suppose he "won" the cosmetic patent for it simply by getting there first.

But I believe he was the first to use EGF as a cosmetic for skincare.

Even so, I'm still sticking with it b/c of the formulation and not gonna try and re-create it myself.

Thanks for digging that up Katee.

free skin care · Sat Apr 22, 2006 2:28 pm

Oh! And Thanks Jonatan for posting the steps for producing growth factors. Very interesting!

free skin care · Sat Apr 22, 2006 4:13 pm

The damn thing is I think it's a good line!!! No reason AT ALL for them to be so darn misleading...

free skin care · Sat Apr 22, 2006 5:52 pm

It is a shame and just not neccessary.

free skin care · Mon Apr 24, 2006 12:06 pm

I still have to say that I cannot find anthing is the steps Jonatan listed that show the source being human nor human recombinant. It says nothing about the source, only the same method. There lies the difference. The source is what makes Revive so expensive and better. NO WAY could you get human based EGF or KGF so inexpensively. A web search will show you that human recombinant growth factors are very, very expensive...tens of thousands of dollars per gram. In the millions for KGF I was told. Some supply houses list their prices on the web; consumers can't purchase growth factors from them, only research facilities, but it will give you an idea of the price of actually human recombinant factors...and, many of these suppliers also list the prices of their synthetic or animal-sourced growth factors.

Even if the growth factors aren't plant-based, they could be animal-based (bovine, equoine and pocine are most commonly available and far cheaper than human recombinant.)

As far as TNS, there were stories posted about TNS affecting menstrual cycles on women who were not peri-menupausal or menepausal. Their cycles were shortened. And none have irregular cycles. Too much of a cooincidence and just wouldn't mess with that.

And as far as Dematologists (I've only heard of Pat Wexler who has her own line to promote now) how does anyone know if they are or are not compensated for promoting TNS.

free skin care · Mon Apr 24, 2006 7:13 pm

[quote="wenrwdy@aol.com"]As far as TNS, there were stories posted about TNS affecting menstrual cycles on women who were not peri-menupausal or menepausal. Their cycles were shortened. And none have irregular cycles. Too much of a cooincidence and just wouldn't mess with that.

Wendy,
Would you mind sharing where you read these stories? I find it hard to believe that a cosmecuetical could mess with someone's system. It is my understanding that "active ingredients" found in skincare products cannot permeate the dermis, if so than it would have to be approved by the FDA and would no longer be a cosmecuetical but a drug. Maybe I'm misunderstanding the post, but am curious to know where these stories can be found--perhaps an urban myth, no? TIA

free skin care · Tue Apr 25, 2006 6:14 am

Before switching to IS Clinical, I used to slather TNS Recovery Complex all over my face and neck and I NEVER had a problem with my menstrual cycle (hell, if I thought it would stop my period, I'd have eaten the stuff Laughing

). As to its effectiveness, no question that it's a good product, but it takes time and it isn't one of those things that feels luxurious AT ALL.

When I mentioned that it is recommended by dermatologists, I didn't mean that they were "endorsers" - what I meant was that reputable dermatologists, many of whom DO NOT sell any products out of their practices, recommend it very highly. My own dermatologist, who actually has a sweet deal with Lancome as their medical consultant (and I should note that she has NEVER recommended a single Lancome product to me or anyone I know), has always said that she thinks TNS Recovery Complex is one of the better products out there. Ironically, I found out that she uses IS Clinical herself, but I didn't find that out until I asked her about it!

I think we've all learned that different products work for different people. What may be a HG product to one of us is often anathema to another. I have no problem understanding that at all. BUT, when I read these accounts of women who claim these extreme maladies after using this or that product, or undergoing this or that procedure, I always think that, in the case of a skin product, they're shills sent out by a competitor. When it's some procedure or other, I often wonder about just WHO did the procedure and whether or not they were competent. And then, of course, there are some accounts that one reads where the only reasonable conclusion is that you're reading the account of somebody who was one slice short of a sandwich to start with Embarassed

...

free skin care · Tue Apr 25, 2006 12:45 pm

I understand your concerns and your observations may be true with SOME. But that cannot apply to all or even most. One of those who claimed this happened to her was a very intelligent and knowledgable person who had been posting on the boards for a long time AND whos opinion was valued by many. She had never made an observation or expressed her opinion about anything without some data to back it up. In fact she was the one who pointed out that nothing else besides KGF in the "soup" of growth factors in TNS can be indentified and it was cause for concern. She actually did the research after having the problems. I mean c'mon. If the company cannot even disclose a COMPLETE list of the ingedients but just something labled "Nouricel" with a bunch of mysterious GFs in it, there is a problem. And when several women claim they had the same reactions, that is a problem. Sure it would be great to have a shorter period, but when something physiological like that is affected, THAT is pretty scary.

But this was a small percentage. Like a lot of products, a small percentage may have adverse reactions. Doesn't mean everyone will.
I think it is a good idea that people post EVERY reaction they have to products so others know what to do and like anything you may have an alergic reaction to, you stop using it. It is a very responsible thing to do. And everyone else can use that info any way THEY choose to use it.

free skin care · Wed Apr 26, 2006 6:30 am

TNS is my HG - not all creams work for everybody - this has made my skin firmmer and refined. I love it! I love it!.......will keep an eye on my periods, though! Laughing

free skin care · Wed Feb 14, 2007 5:50 pm

jonatan wrote:

Our growth factors are made through biotechnology in the same way the ReVive makes it. It is the only way that EGF and KGF are made in the modern era.

Step 1: many people have already worked very hard to find the amino acid sequence of the growth factor. From this sequence of amino acid a scientist works out what nucleotide sequence will tranlate into THAT amino acid sequence

Step 2: by several steps (several little pieces of DNA are synthesized chemically, the pieces are put together in the right sequence with the help of special enzymes), the scientist obtains a piece of DNA with the right sequence of nucleotides. The sequence has to be checked and re-checked, otherwise everything that comes afterwards is a waste of time

Step 3: the piece of DNA, designed as per steps 1 and 2 is inserted inside a piece of DNA, called plasmid, that has the right structure to be duplicated by a bacterium or yeast cell.

Step 4: the plasmid, now containing the piece of DNA that "codes" for our growth factor, is inserted in a bacteria or yeast.

Step 5: the cells containing the plasmid are cultured and at a certain point, a chemical order is given to the cells to start making the growth factor (or whatever is coded in that plasmid)

Step 6: the cells, full of our protein (sometimes as much as half of the total protein) are removed from the liquid medium, and broken to release the contents.

Step 7: the protein of interest is purified from the other "stuff" by a series of protein purification methods.

Step 8: the pure protein is precipitated in a concentrated ammonium sulfate solution to preserve the integrity and activity of the protein.

It is not an easy process and it takes dozens of years of experience in the process and about a year to confirm the sequence of the protein.

Isn't your egf made by impregnating cauliflower florets with a yeast? I don't think that it is human recombinant? I'm also led to believe that SAS manufacture their egf in an Argentinian university laboratory.

free skin care · Thu Feb 15, 2007 1:34 pm

I bought both the ReVive eye serum & cream in October and think they're good products. Will I purchase again? Probably not. I wasn't blown away by the results.

Thu Feb 15, 2007 5:32 pm

I am currently using (for about a year now) the Moisturizing Renewal Cream, Eye Renewal Cream, and the Sensitif Cellular Repair Cream. I like the consistency of the Eye Renewal Cream, but I have not noticed anything great, so I do not plan to repurchase. I have had a lot of redness, sensitivity and skin texture issues. The Moisturizing Renewal Cream and the Sensitif Cellular Repair Cream have helped a lot with the redness and sensitivity. My skin does have that glow that they talk about on the website. I have used the Intensite Volumizing Serum, but didn’t notice any ‘volume enhancement’ or improvement in dark spots. I tried to use the Arrete Booster C, but it always makes my face break out. AND, believe it or not, I tried the Peau Magnifque at $1,500 back in June Embarassed

. It says it resets your skin’s aging clock by a minimum of 5 years. I honestly did not notice any significant changes and would not repurchase.

free skin care · Thu Feb 15, 2007 6:43 pm

Mossa wrote:

I am currently using (for about a year now) the Moisturizing Renewal Cream, Eye Renewal Cream, and the Sensitif Cellular Repair Cream. I like the consistency of the Eye Renewal Cream, but I have not noticed anything great, so I do not plan to repurchase. I have had a lot of redness, sensitivity and skin texture issues. The Moisturizing Renewal Cream and the Sensitif Cellular Repair Cream have helped a lot with the redness and sensitivity. My skin does have that glow that they talk about on the website. I have used the Intensite Volumizing Serum, but didn’t notice any ‘volume enhancement’ or improvement in dark spots. I tried to use the Arrete Booster C, but it always makes my face break out. AND, believe it or not, I tried the Peau Magnifque at $1,500 back in June Embarassed

. It says it resets your skin’s aging clock by a minimum of 5 years. I honestly did not notice any significant changes and would not repurchase.

That sucks.. Crying or Very sad

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