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Sat May 26, 2007 4:08 am  |
A combination of 2% erythromycin;and 0.05% tretinoin in an alcohol-isopropanol lotion was prepared. Two parameters were investigated for their influence on the stability of erythromycin and/or tretinoin, namely pH and the concentration of butylhydroxytoluene (BHT) as antioxidant. To investigate these two parameters, an optimization technique was used with two factors (pH and concentration of BHT) at two levels. Accelerated stability analysis was performed at 45 degrees C in the dark to exclude isomerization of tretinoin. To analyse erythromycin and tretinoin in the combination preparation, a TLC method, previously developed in the laboratory, was used. The degradation of erythromycin seemed to be much faster than the tretinoin degradation. Optimal stability is shown in the pH range of 8.2-8.6 for erythromycin and 7.2-8.2 for tretinoin while the concentration of BHT had no significant influence. (C) 2000 Elsevier Science B.V. All rights reserved.
Title: Investigation of the chemical stability of an erythromycin-tretinoin lotion by the use of an optimization system
Author(s): Brisaert M, Gabriels M, Plazier-Vercammen J
Source: INTERNATIONAL JOURNAL OF PHARMACEUTICS 197 (1-2): 153-160 MAR 20 2000 |
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